• Randomly assigning patients in a clinical quality registry combines the features of a prospective randomized trial with a large-scale clinical registry • Registry-based trials are less selective and ...

Anyone who’s read my stuff with any regularity is acutely aware of my disdain for the way many observational studies are conducted and interpreted in health and nutrition research, as well as my ...

Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy. Two hundred seventy-four ...

We conducted a pragmatic, nonblinded, noninferiority, randomized trial comparing antibiotic therapy (10-day course) with appendectomy in patients with appendicitis at 25 U.S. centers. The primary ...

The choice of drugs for patients with status epilepticus that is refractory to treatment with benzodiazepines has not been thoroughly studied. In a randomized, blinded, adaptive trial, we compared the ...

Randomized controlled trials are clinical trials in which at least two interventions — the test treatment and a control treatment — are simultaneously evaluated in two or more arms of the trial, with ...

Outcomes of VAC temporization following the excision of microinvasive sarcomas pending negative formal pathologic margins. ‘I’m being forced to make decisions I have never had to make before’: ...

Randomized controlled trials are the most reliable method available for testing new treatments. They have become the standard that pharmaceutical companies must meet for calculating and proving the ...

Randomized, blinded clinical study evaluating injectable autologous hair follicle secretome in patients with androgenic ...