Left untreated, PNH could cause death in about half of patients within 10 years of diagnosis. The primary cause of PNH-related mortality is thromboembolic events. A host of anti-complement strategies, ...
The complement system is an important part of the innate immune system that participates in tissue injury in a number of inflammatory and autoimmune diseases. Polymorphisms in genes that encode ...
The complement system serves many biological functions, including the eradication of invasive pathogens and the removal of damaged cells and immune-complexes. Uncontrolled complement activation causes ...
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